Multiple loci influence erythrocyte phenotypes in the CHARGE consortium.

/in /by

Ganesh SK, Zakai NA, van Rooij FJ, Soranzo N, Smith AV, Nalls MA, Chen MH, Kottgen A, Glazer NL, Dehghan A, Kuhnel B, Aspelund T, Yang Q, Tanaka T, Jaffe A, Bis JC, Verwoert GC, Teumer A, Fox CS, Guralnik JM, Ehret GB, Rice K, Felix JF, Rendon A, Eiriksdottir G, Levy D, Patel KV, Boerwinkle E, Rotter JI, Hofman A, Sambrook JG, Hernandez DG, Zheng G, Bandinelli S, Singleton AB, Coresh J, Lumley T, Uitterlinden AG, Vangils JM, Launer LJ, Cupples LA, Oostra BA, Zwaginga JJ, Ouwehand WH, Thein SL, Meisinger C, Deloukas P, Nauck M, Spector TD, Gieger C, Gudnason V, van Duijn CM, Psaty BM, Ferrucci L, Chakravarti A, Greinacher A, O’Donnell CJ, Witteman JC, Furth S, Cushman M, Harris TB, Lin JP: Multiple loci influence erythrocyte phenotypes in the CHARGE consortium. Nature Genet 41:1191-1198, 2009. PMID 19862010. PMC2778265.

Understanding cardiovascular disease through the lens of genome wide association studies.

/in /by

Arking DE, Chakravarti A: Understanding cardiovascular disease through the lens of genome wide association studies. Trends Genet 25:387-394, 2009. PMID 19716196.

A genome-wide linkage and association scan reveals novel genes for autism.

/in /by

Weiss L, Arking DE, The Gene Discovery Project of Johns Hopkins and the Autism Consortium: A genome-wide linkage and association scan reveals novel genes for autism. Nature 461:802-808, 2009. PMID 19812673. PMC2772655.

A drug-sensitized zebrafish screen identifies multiple genes, including GINS3, as regulators of myocardial repolarization.

/in /by

Milan DJ, Kim AM, Winterfield JR, Jones IL, Pfeufer A, Sanna S, Arking DE, Amsterdam AH, Sabeh KM, Mably JD, Rosenbaum DS, Peterson RT, Chakravarti A, Kääb S, Roden DM, MacRae CA: A drug-sensitized zebrafish screen identifies multiple genes, including GINS3, as regulators of myocardial repolarization. Circulation 120:553-559, 2009. PMID 19652097. PMC2771327.

Follow-up of a major linkage peak on chromosome 1 reveals multiple QTLs associated with essential hypertension: The GenNet study.

/in /by

Ehret GE, O’Connor AA, Weder A, Cooper RS, Chakravarti A: Follow-up of a major linkage peak on chromosome 1 reveals multiple QTLs associated with essential hypertension: The GenNet study. Eur J Hum Genet 17:1650-1657, 2009. PMID 19536175. PMC2783544.

Genome-wide Association Study of Blood Pressure and Hypertension.

/in /by

Levy D, Ehret GB, Rice K, Verwoert GC, Launer LJ, Dehghan A, Glazer NL, Morrison AC, Johnson AD, Aspelund T, Aulchenko Y, Lumley T, Köttgen A, Vasan RS, Rivadeneira F, Eiriksdottir G,Guo X, Arking DE, Mitchell GF, Mattace-Raso FU, Smith AV, Taylor K, Scharpf RB, Hwang SJ, Sijbrands EJ, Bis J, Harris TB, Ganesh SK, O’Donnell CJ, Hofman A, Rotter JI, Coresh J, Benjamin EJ, Uitterlinden AG, Heiss G, Fox CS, Witteman JC, Boerwinkle E, Wang TJ, Gudnason V, Larson MG, Chakravarti A, Psaty BM, van Duijn CM: Genome-wide Association Study of Blood Pressure and Hypertension. Nat Genet 41:677-687, 2009. PMID 19430479. PMC2998712.

Positional identification of variants of ADAMTS16 linked to inherited hypertension.

/in /by

Joe B, Saad Y, Dhindaw S, Lee NH, Frank BC, Achinike OH, Luu TV, Gopalakrishnan K, Toland EJ, Farms P, Yerga-Woolwine S, Manickavasagam E, Rapp JP, Garrett MR, Coe D, Apte SS, Rankinen T, Pérusse L, Ehret GB, Ganesh SK, Cooper RS, O’Connor A, Rice T, Weder AB, Chakravarti A, Rao DC, Bouchard C: Positional identification of variants of ADAMTS16 linked to inherited hypertension. Hum Mol Genet 18:2825-2838, 2009. PMID 19423552. PMC2706685.

The Association of Cell Cycle Checkpoint 2 Variants and Kidney Function: Findings of the Family Blood Pressure Program and the Atherosclerosis Risk in Communities Study.

/in /by

Franceschini N, North KE, Arnett D, Pankow JS, Chung JH, Baird L, Leppert MF, Eckfeldt JH, Boerwinkle E, Gu CC, Lewis CE, Myers RH, Turner ST, Weder A, Kao WH, Mosley TH, Chakravarti A, Kramer H, Zhang J, Hunt SC: The Association of Cell Cycle Checkpoint 2 Variants and Kidney Function: Findings of the Family Blood Pressure Program and the Atherosclerosis Risk in Communities Study. Amer J Hypertension 22:552-558, 2009. PMID 19265784. PMC2727134.

Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry.

/in /by

Benjamin EJ, Rice KM, Arking DE, Pfeufer A, van Noord C, Smith AV, Schnabel RB, Bis JC, Boerwinkle E, Sinner MF, Dehghan A, Lubitz SA, D’Agostino RB Sr, Lumley T, Ehret GB, Heeringa J, Aspelund T, Newton-Cheh C, Larson MG, Marciante KD, Soliman EZ, Rivadeneira F, Wang TJ, Eiríksdottir G, Levy D, Psaty BM, Li M, Chamberlain AM, Hofman A, Vasan RS, Harris TB, Rotter JI, Kao WH, Agarwal SK, Stricker BH, Wang K, Launer LJ, Smith NL, Chakravarti A, Uitterlinden AG, Wolf PA, Sotoodehnia N, Köttgen A, van Duijn CM, Meitinger T, Mueller M, Perz S, Steinbeck G, Wichmann HE, Lunetta KL, Heckbert SR, Gudnason V, Alonso A, Kääb S, Ellinor PT, Witteman JC: Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry. Nat Genet 41:879-881, 2009. PMID 19597492. PMC2761746.

Mitochondrial DNA Variants of Respiratory Complex 1 that Uniquely Characterize Haplogroup T2 are Associated with Increased Risk of Advanced AMD.

/in /by

SanGiovanni JP, Arking D, Iyengar S, Elashoff M, Clemons TE, Reed GF, Henning AK, Sivkumaran TA, Xu X, DeWan A, Agrón E, Rochtchina E, Wang JJ, Mitchell P, Hoh J, Francis PJ, Klein ML, Chew EY, Chakravarti A: Mitochondrial DNA Variants of Respiratory Complex 1 that Uniquely Characterize Haplogroup T2 are Associated with Increased Risk of Advanced AMD. PLoS One 4(5):e5508, 2009. PMID 19434233. PMC2677106.