Genome-Wide Association Study Identifies GPC5 as a Novel Genetic Locus Protective against Sudden Cardiac Arrest.

Arking DE, Reinier K, Post W, Jui J, Hilton G, O’Connor A, Prineas RJ, Boerwinkle E,Psaty BM, Tomaselli GF, Rea T, Sotoodehnia N, Siscovick DS, Burke GL, Marban E, Spooner PM, Chakravarti A, Chugh SS: Genome-Wide Association Study Identifies GPC5 as a Novel Genetic Locus Protective against Sudden Cardiac Arrest. PLoS One 5:e9879, 2010. PMID 20360844. PMC2845611.

PRINCIPIA GENETICA: Our Future Science.

Chakravarti A: PRINCIPIA GENETICA: Our Future Science. Amer J Hum Genet 86:302-308, 2010. PMC2833370.

CommonVariants in KCNN3 are Associated with Lone Atrial Fibrillation.

Ellinor PT, Lunetta KL, Glazer NL, Pfeufer A, Alonso A, Chung MK, Sinner MF, de Bakker PI, Mueller M, Lubitz SA, Fox E, Darbar D, Smith NL, Smith JD, Schnabel RB, Soliman EZ, Rice KM, Van Wagoner DR, Beckmann BM, van Noord C, Wang K, Ehret GB, Rotter JI, Hazen SL, Steinbeck G, Smith AV, Launer LJ, Harris TB, Makino S, Nelis M, Milan DJ, Perz S, Esko T, Köttgen A, Moebus S, Newton-Cheh C, Li M, Möhlenkamp S, Wang TJ, Kao WH, Vasan RS, Nöthen MM, MacRae CA, Stricker BH, Hofman A, Uitterlinden AG, Levy D, Boerwinkle E, Metspalu A, Topol EJ, Chakravarti A, Gudnason V, Psaty BM, Roden DM, Meitinger T, Wichmann HE, Witteman JC, Barnard J, Arking DE, Benjamin EJ, Heckbert SR, Kääb S: CommonVariants in KCNN3 are Associated with Lone Atrial Fibrillation. Nat Genet 42:240-244, 2010. PMID 20173747. PMC2871387.

Transcobalamin-II variants, decreased Vitamin B12 availability and increased risk of fraility.

Matteini AM, Walston JD, Bandeen-Roche K, Arking DE, Allen RH, Fried LP, Chakravarti A, Stabler SP, Fallin MD: Transcobalamin-II variants, decreased Vitamin B12 availability and increased risk of fraility. J Nutr Health Aging 14:73-77, 2010. PMID 20082058. PMC3062247.

Genome-wide association study of PR interval.

Pfeufer A, van Noord C, Marciante KD, Arking DE, Larson MG, Smith AV, Tarasov KV, Müller M, Sotoodehnia N, Sinner MF, Verwoert GC, Li M, Kao WH, Köttgen A, Coresh J, Bis JC, Psaty BM, Rice K, Rotter JI, Rivadeneira F, Hofman A, Kors JA, Stricker BH, Uitterlinden AG, van Duijn CM, Beckmann BM, Sauter W, Gieger C, Lubitz SA, Newton-Cheh C, Wang TJ, Magnani JW, Schnabel RB, Chung MK, Barnard J, Smith JD, Van Wagoner DR, Vasan RS, Aspelund T, Eiriksdottir G, Harris TB, Launer LJ, Najjar SS, Lakatta E, Schlessinger D, Uda M, Abecasis GR, Müller-Myhsok B, Ehret GB, Boerwinkle E, Chakravarti A, Soliman EZ, Lunetta KL, Perz S, Wichmann HE, Meitinger T, Levy D, Gudnason V, Ellinor PT, Sanna S, Kääb S, Witteman JC, Alonso A, Benjamin EJ, Heckbert SR: Genome-wide association study of PR interval. Nat Genet 42:153-159, 2010. PMID 20062060. PMC2850197.

NOS1AP variant associated with incidence of type 2 diabetes in calcium channel blocker users in the Atherosclerosis Risk in Communities (ARIC) study.

Chu AY, Coresh J, Arking DE, Pankow JS, Tomaselli GF, Chakravarti A, Post WS, Spooner PH, Boerwinkle E, Kao WH: NOS1AP variant associated with incidence of type 2 diabetes in calcium channel blocker users in the Atherosclerosis Risk in Communities (ARIC) study. Diabetologia 53:510-516, 2010. PMID 19943157. PMC3039128.

Variation in the checkpoint kinase 2 gene is associated with type 2 diabetes in multiple populations.

North KE, Franceschini N, Avery CL, Baird L, Graff M, Leppert M, Chung JH, Zhang J, Hanis C, Boerwinkle E, Volcik KA, Grove ML, Mosley TH, Gu C, Heiss G, Pankow JS, Couper DJ, Ballantyne CM, Linda Kao WH, Weder AB, Cooper RS, Ehret GB, O’Connor AA, Chakravarti A, Hunt SC: Variation in the checkpoint kinase 2 gene is associated with type 2 diabetes in multiple populations. Acta Diabetol 47:199-207, 2010. PMID 19855918. PMC1965317.

Diabetes and the risk of sudden cardiac death, the Atherosclerosis Risk in Communities study.

Kucharska-Newton AM, Couper DJ, Pankow JS, Prineas RJ, Rea TD, Sotoodehnia N, Chakravarti A, Folsom AR, Siscovick DS, Rosamond WD: Diabetes and the risk of sudden cardiac death, the Atherosclerosis Risk in Communities study. Acta Diabetol 47:161-168, 2010. PMID 19855920. PMC3064263.

Hemostasis, inflammation and fatal and non-fatal coronary heart disease: long-term follow-up of the Atherosclerosis Risk in Communities (ARIC) cohort.

Kucharska-Newton AM, Couper DJ, Pankow JS, Prineas RJ, Rea TD, Sotoodehnia N, Chakravarti A, Folsom AR, Siscovick DS, Rosamond WD: Hemostasis, inflammation and fatal and non-fatal coronary heart disease: long-term follow-up of the Atherosclerosis Risk in Communities (ARIC) cohort. Arterio Thromb Vasc Biol 29:2182-2190, 2009. PMID 19797708. PMC3057473.

Finding the missing heritability of complex diseases.

Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, McCarthy MI, Ramos EM, Cardon LR, Chakravarti A, Cho JH, Guttmacher AE, Kong A, Kruglyak L, Mardis E, Rotimi CN, Slatkin M, Valle D, Whittemore AS, Boehnke M, Clark AG, Eichler EE, Gibson G, Haines JL, Mackay TF, McCarroll SA, Visscher PM: Finding the missing heritability of complex diseases. Nature 461:747- 753, 2009. PMID 19812666. PMC2831613.