Senior Research Scientist
I was trained as a zoologist in my undergraduate (University of Delhi, India) and a developmental biologist in my PhD (National University of Singapore, Singapore) where I acquired my love for model organisms and their utility in understanding biology, both basic and translational.
My research interest has been to decipher how the information encoded in our genome is translated to all the cellular diversity we see and how disruption in the information flow causes diseases.
Currently I am looking at the gene regulatory networks involved in enteric neuron formation and how disruption of these cause Hirschsprung disease, both in whole tissues and single cells.
Chatterjee S and Ahituv N. Gene Regulatory Elements, Major drivers of Human Disease. Annu Rev Genomics Hum Genet. 2017;doi:10.1146/annurev-genom-091416-035537.
Chatterjee S, Kapoor A, Akiyama JA, Auer DR, Lee D, Gabriel S, Berrios C, Pennacchio LA, and Chakravarti A. Enhancer variants synergistically drive dysfunction of a gene regulatory network in Hirschsprung disease. Cell. 2016;167, 355-368.
Kapoor A, Jiang Q, Chatterjee S, Chakraborty P, Sosa MX, Berrios C, and Chakravarti A. Population variation in total genetic risk of Hirschsprung disease from common RET, SEMA3 and NRG1 susceptibility polymorphisms. Hum Mol Genet. 2015; 24, 2997-3003.