B.S. Biological Sciences, Carnegie Mellon University
My thesis and research interests center around study of sequence variants and genes involved in blood pressure regulation, and generally extend to the study of genomics of complex disease. Impending analysis will focus on whole-genome sequence data from four different ethnic groups within the RPGEH GERA study, which enables us to examine coding and non-coding variants, as well as their interplay and within the context of genes, across different populations. Thousands of individuals will be drawn from the extremes of the systolic blood pressure distribution to maximize identification of potentially causal low-frequency and rare variants associated with blood pressure. This study design and the large sample size will particularly allow us to evaluate the impact of rare variants in known monogenic forms of hypertension.