Ashish Kapoor

ASHISH KAPOOR
Research Associate

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I obtained my B.Sc. in Zoology and M.Sc. in Genetics from University of Delhi, Delhi and obtained my Ph.D. in the laboratory of Anuranjan Anand at the Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore. I joined the laboratory of Aravinda Chakravarti as a postdoctoral fellow, where I am currently working as a Research Associate. I have a broad background and training in molecular biology, genetics and genomics and my research work has involved the elucidation of the genetic and molecular basis of human diseases and traits. My doctoral thesis work was on characterization of molecular genetic basis of idiopathic generalized epilepsies. In my postdoctoral work, I have functionally characterized electrocardiographic QT interval associated loci, mapped by genome-wide association studies, to identify the molecular basis of these genetic associations. These studies have uncovered cis-regulatory elements and their variant forms that influence target gene expression and function, and thus underlie inter-individual trait variation. I have also evaluated the population variation in genetic risk of Hirschsprung disease from known common susceptibility polymorphisms.

Selected publications:

Kapoor A, Sekar RB, Hansen NF, Fox-Talbot K, Morley M, Pihur V, Chatterjee S, Brandimarto J, Moravec CS, Pulit SL, QTIGC, Pfeufer A, Mullikin J, Ross M, Green ED, Bentley D, Newton-Cheh C, Boerwinkle E, Tomaselli GF, Cappola TP, Arking DE, Halushka MK, Chakravarti A. An enhancer polymorphism at the cardiomyocyte intercalated disc protein NOS1AP locus is a major regulator of the QT interval. Am J Hum Genet 2014; 94:854-869.

Kapoor A, Jiang Q, Chatterjee S, Chakraborty P, Sosa MX, Berrios C, Chakravarti A. Population variation in total genetic risk of Hirschsprung disease from common RET, SEMA3 and NRG1 susceptibility polymorphisms. Hum Mol Genet 2015; 24:2997-3003.